The complete identification of coding sequences in a number of species has led to announce the beginning of the post-genomic era. Rapid advances in genomic sequencing and the applications of new biotechnology have made it available to study complex phenomena in biological system. As a recently identified type of modification, Small ubiquitin-related modifier (SUMO) conjugation or sumoylation, which is a highly dynamic reversible process and its outcomes are extremely diverse, ranging from changes in localization to altered activity and, in some cases, stability of the modified, has shown to be especially valuable in cellular biology. Motivated by the importance of SUMO conjugation in biological processes, we report here on the first exploratory assess whether sumoylation related genetic variability impacts protein functions and the occurrence of diseases related to SUMO. Here, we defined the SUMOAMVR as sumoylation related amino acid variations that affect sumoylation sites or enzymes involved in the process of connectivity, and categorized four types of potential SUMOAMVR.And
it can be anticipated our method can provide more instructive guidance to
identify the mechanisms of genetic diseases.